Historically both physicians and patients would reason that a person's genetics are simply a part of who they are and that there is nothing we can do about this genetic situation. Since the Human Genome project was completed in the late 1990's, we have learned quite a bit more about genetic disorders and how they work. When the United States government provided 3 companies one billion dollars each to diligently research genetic information, we have been receiving regular genetic information that is filling in the pieces to many puzzles. We are beginning to have medications that alter the genetic expressions of certain diseases (i.e. Actos has the ability to enter the nucleus of the insulin resistant cell and down-regulate the genetic expression of that cell). We have other medications that simply bypass the problem caused by the genetic condition (i.e Deplin is the L isomer of methylfolate, capable of overriding much of the problems caused by the genetic lack of the enzyme, methylenetetrahydrofolate reductase, in MTHFR genetic abnormality patients). We should uncover more ways to overcome many genetic problems in the future and this could lead to a significant reduction of cardiovascular disease states. Gone are the days that we should give up on a patient because they have a genetic barrier to overcome. Abnormal genetics are not necessarily the "plight" of a person in the present generation of medical advances.