Chronic Kidney Disease (CKD) usually occurs as a result of chronic inflammation that ultimately damages the kidneys glomerular filtration system, which essentially is a modified form of blood vessel within the kidneys that perform numerous functions. It is uncertain why the chronic inflammation seen in some patients leaves the patients untouched while other causes of chronic inflammation cause significant CKD but there clearly is a relationship between the inflammation and CKD. Once CKD develops, it becomes a source of chronic inflammation, partly due to the decreased effectiveness of eliminating impurities. CKD also causes indirect problems with inflammation such as the problems associated with decreased production of erythropoietin which ultimately causes prolonged anemia issues. When a person is significantly anemic for even one year there is a 33% occurrence of left ventricular hypertrophy in that person. The increased sympathetic tone that occurs with this prolonged anemia further stimulates an inflammatory response. CKD needs to detected early to prevent the development of erythropoietin deficiency as we erythropoietin deficiency problems often show up when a person is in the early part of Stage III CKD.